Narcotic Cloud Nine was blamed for the attack when Rudy Eugene ate 75% of homeless man Ronald Poppo’s face in Miami last month.
Horrific images surfaced of the attack that only ended once police shot and killed 31-year-old Eugene.
Mr Poppo is still recovering from his injuries in hospital.
Police are now warning people to stay away from Cloud Nine – also known as ‘bath salts’ - after two similar attacks were reported.
The most recent prompted an internal memo to police warning officers the case “bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man’s face”.
The memo called the synthetic drug “addictive and dangerous” and said it was part of a “disturbing trend in which new drugs are sold in the guise of household products”.
It added: “Please be careful when dealing with the homeless population during your patrols.”
Rudy Eugene, 31: Ate 75% of a man's face in Miami before being shot dead
Brandon De Leon, 21: Tried to bite two police officers after he was arrested in North Miami BeachCarl Jacquneaux, 43: Bit a man's face in Scott, Louisiania. Wasp spray was used to end the attackAlex Kinyua, 21: Accused of eating the heart and brain of friend in Maryland
Horror: Film cannibal Hannibal Lecter
During the latest attack homeless Brendon De Leon threatened to eat two Miami police officers and had to be fitted with a Hannibal Lecter-style mask to prevent him carrying his threats out.
He had been arrested for disturbing the peace in North Miami Beach while high on drugs and put in a police cruiser when he slammed his head against the plexiglass divider and shouted: “I’m going to eat you” to officers before growling and baring his teeth.
Miami police said they believe he was on a cocktail of drugs including Cloud Nine.
In another case, Carl Jacquneaux, 43, was accused of attacking Todd Credeur in his front garden in Scott, Louisiana, over the weekend after being upset over a domestic issue while under the influence of what is said to be bath salts.
Jacquneaux bit Mr Credeur before being sprayed in the face with wasp spray.
Scott Assistant Police Chief Kert Thomas said: “During the attack, the suspect bit a chunk of the victim’s face off.”
Jacquneaux was then said to have left the property and gone to another man’s home where he held him at knife-point and stole a handgun before being apprehended by police.
The drug, which is also known as Ivory Wave, was blamed for several deaths in Britain during 2010 before being banned. It is also illegal in Australia.
The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour and is often sold in plain packaging with the contents purporting to be harmless.